HIGHLIGHTS
- who: Dundee and collaborators from the University of have published the research work: Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase, in the Journal: Neurology, of 17/Oct/2017
- what: The authors demonstrate that the MJFF-pRAB10 antibodies can be deployed to assess enhanced phosphorylation resulting from pathogenic (R1441C/G or G2019S) knock-in mutations as well as the impact of inhibitor treatment. The authors describe the efforts to develop polyclonal and monoclonal_antibodies towards LRRK2-phosphorylated Rab proteins and the approach to rigorously assess . . .
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