Btk sh2-kinase interface is critical for allosteric kinase activation and its targeting inhibits b-cell neoplasms

HIGHLIGHTS

• who: Daniel P. Duarte from the Institut of Molecular Modeling and Drug Discovery, Istituto Italiano di Tecnologia, Via Morego, Genoa, ItalyUniversity of have published the Article: Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that, based on the analysis of XLA mutations in the SH2 domain, Btk activation critically depends on the formation of an allosteric interface between its SH2 and the N-lobe of kinase domain, which the authors mapped using a combination of . . .
  

   

  

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