Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor ù³*

HIGHLIGHTS

• who: Yifei Wu from the (UNIVERSITY) have published the Article: Ligand and Coactivator Identity Determines the Requirement of the Charge Clamp for Coactivation of the Peroxisome Proliferator-activated Receptor Ù³*, in the Journal: (JOURNAL) of October/24,/2002
• what: The authors show that the peroxisome proliferator-activated receptor ␥ (PPAR␥) (NR1C3) coactivator-1 (PGC-1) requires both the intact AF-2 domain of PPAR␥ and the LXXLL domain of PGC-1 for ligand-dependent and ligand-independent interaction and coactivation. The authors demonstrate that coactivation of PPAR␥ by PGC-1 indeed depends on the AF-2 domain . . .
  

   

  

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