Local delivery of aav2-ctla4igg decreases sialadenitis and improves gland function in the c57bl/6.nod- aec1aec2 mouse model of sjögren ’ s syndrome

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• who: Hongen Yin et al. from the (Institute of Immunological Science, Hokkaido University, Hokkaido, Japan) [24]This gene was cloned into the recombinant adeno-associated virus (AAV) plasmid containing a cytomegalovirus (CMV) promoter and the inverted terminal repeat (ITRs) sequences for AAV serotype , (AAV2). The plasmid (AAV2-CTLA IgG) was transfected into HEK- T cells and expression of the protein in the media was determined by western blotting after electrophoresis in reducing conditions using anti-m, Ab (RandD systems, Minneapolis, MN, USA). Competitive inhibition of , association by CTLA IgG in vitro have published the Article: Local delivery . . .
  

   

  

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