Shp1 and shp2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia

HIGHLIGHTS

  • who: Alejandro Pérez-Fernández from the Department of Biochemistry and Molecular Biology, University of, Spain have published the Article: SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia, in the Journal: (JOURNAL)
  • what: This work has been developed based on two different phenomena: the ability of phorbol esters to induce cell differentiation , and the involvement of redox signaling in this process .

SUMMARY

    Hematopoiesis is a paradigmatic differentiation process where a single cell type, the hematopoietic stem_cell (HSC), gives rise . . .

     

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