HIGHLIGHTS
- who: Burkitkan Akbay and collaborators from the CNRS UMR, Université Paris-Saclay, Institut Gustave Roussy, rue Édouard Vaillant, Villejuif, Villejuif, France have published the paper: Modulation of mTORC1 Signaling Pathway by HIV-1, in the Journal: (JOURNAL)
- what: The main reason for rapalogue inefficiency is related to the activation of alternative proliferation pathways and genetic and functional intratumoral heterogeneity of mTORC1 activity .
SUMMARY
HIV-1 infection is generally associated with inhibition of mTORC1 in CD4 T_cells at the early stage of infection and the activation of mTORC1 at the late stage . . .
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