HIGHLIGHTS
- who: Stefan F. Lichtenthaler from the German Center forTechnical University München, Munich, Germany have published the article: To cut or not to cut: New rules for proteolytic shedding of membrane proteins, in the Journal: (JOURNAL)
- how: The study analyzed the ADAM17-mediated shedding of the activated leukocyte cell adhesion molecule (ALCAM) which is crucial for the entrance of B cells into the brain in neuroinflammatory diseases such as multiple sclerosis .
- future: Study is needed to uncover strategies for how transmembrane proteins avoid sheddase activity. Future studies need to address the exact mechanism . . .
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