Oxidative stress, neuroinflammation and mitochondria in the pathophysiology of amyotrophic lateral sclerosis

HIGHLIGHTS

• who: Elena Obrador and colleagues from the Department of Physiology, Faculty of Medicine and Odontology, University of Valencia, AvBlasco Ibañez have published the paper: Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis, in the Journal: Antioxidants 2020, 901 of /2020/

SUMMARY

Amyotrophic lateral sclerosis (ALS), the most common motor neuron (MN) disease, is considered a rare disease based on its prevalence (2-3 cases per 100,000 people with European ancestry). Activated microglia release proinflammatory cytokines (e_g, TNFα, IL1β, IL12, IFNγ), mitogenic factors (e_g, MCP-1, M-CSF . . .

 



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