How aromatic compounds block dna binding of hcar catabolite regulator*

HIGHLIGHTS

• who: Youngchang Kim from the (UNIVERSITY) have published the paper: How Aromatic Compounds Block DNA Binding of HcaR Catabolite Regulator*, in the Journal: (JOURNAL) of June/17,/2016
• what: The authors report several crystal_structures of AcHcaR: the apo form and in a complex with several substrates for the enzymes of the hca catabolic operon including ferulic acid, 3,4-dihydroxybenzoic acid (DHBA), and p-coumaric acid as well as with vanillin, which is a product of ferulic acid processing by hcaABC gene products. The model shows that aromatic ligands are too far from the DNA . . .
  

   

  

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