Nonamyloid aggregates arising from mature copper/zinc superoxide dismutases resemble those observed in amyotrophic lateral sclerosis*

HIGHLIGHTS

• who: Young-Mi Hwang from the (UNIVERSITY) have published the research work: Nonamyloid Aggregates Arising from Mature Copper/Zinc Superoxide Dismutases Resemble Those Observed in Amyotrophic Lateral Sclerosis*, in the Journal: (JOURNAL) of December/31,/2010
• what: The authors report here that incubation of holo SOD1s under physiologically relevant conditions leads to decreases in activity, altered metal binding, and formation of aggregates that have common structural, tinctorial, as well as immunological characteristics with those of aggregates formed in fALS patients.
• how: Taken together the above considerations show that the results are compatible with . . .
  

   

  

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