Structural requirements for activation of latent platelet-derived growth factor cc by tissue plasminogen activator*

HIGHLIGHTS

• who: Linda Fredriksson from the (UNIVERSITY) have published the article: Structural Requirements for Activation of Latent Platelet-derived Growth Factor CC by Tissue Plasminogen Activator*, in the Journal: (JOURNAL) of March/28,/2005
• what: The authors determine the molecular mechanism of tPA-mediated activation of PDGF-CC. The authors demonstrate that both the CUB and the growth factor domains of PDGF-C 26856 This is an Open Access article under the CC BY license. and the kringle-2 domain of tPA are necessary for interaction of the two proteins and that Arg231 in the hinge . . .
  

   

  

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