Major concerns with the integrity of the mitochondrial adp/atp carrier in dodecyl-phosphocholine used for solution nmr studies

HIGHLIGHTS

  • who: from the Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical have published the paper: Major concerns with the integrity of the mitochondrial ADP/ATP carrier in dodecyl-phosphocholine used for solution NMR studies, in the Preprint: biorxiv

SUMMARY

    The subject is the yeast mitochondrial ADP/ATP carrier AAC3, which the authors have studied in great detail ourselves. In this paper, the authors claim that AAC3 can be refolded to homogeneity from inclusion bodies produced in Escherichia coli by using the detergent dodecyl-­‐ phosphocholine (DPC), better known as Foscholine-­‐12 . . .

     

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