Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis

HIGHLIGHTS

• who: Vanessa S. Y. Tay from the Technological University have published the research: Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis, in the Journal: Scientific Reports Scientific Reports
• what: The authors sought to determine whether diabetic β-cells suffered from DSBs to a greater extent compared to non-diabetic β-cells.

SUMMARY

The finding of increased DSB frequency in β-cells of patients with congenital hyperinsulinemia prompted an investigation into DSB presence in β-cells of diabetic mice (db/db mice). The authors further probed DDR gene_expression in primary . . .

 



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