Construction of attenuated strains for red-spotted grouper nervous necrosis virus (rgnnv) via reverse genetic system

HIGHLIGHTS

  • who: Yingying Lei et al. from the State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China have published the research: Construction of Attenuated Strains for Red-Spotted Grouper Nervous Necrosis Virus (RGNNV) via Reverse Genetic System, in the Journal: Viruses 2022, 14, 1737. of /2022/
  • what: The authors constructed attenuated strains rRGNNV-B2-M1 and rRGNNV-B2-M2 with the loss of B2 protein expression which grew slower and induced less Mx1 expression than that of wild-type Moreover rRGNNV-B2-M1 and rRGNNV-B2-M2 were less virulent than the wild-type . . .

     

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