Tet enzymes regulate skeletal development through increasing chromatin accessibility of runx2 target genes

HIGHLIGHTS

• who: Lijun Wang from the Mouse lines Tet1fl/fl Tet2fl/fl Tet3fl/fl mice and Tet1fl/HD Tet2fl/fl Tet3fl/fl mice (gifts from Guoliang Xu, Shanghai Institute of Biochemistry and Cell Biology), were crossed with the Prx1-Cre strain, (a gift from Andrew McMahon, Harvard University) to generate Prx1-Cre, Tet1fl/fl Tet2fl/fl Tet3fl/fl mice, Prx1-Cre, Tet1fl/+ Tet2fl/fl Tet3fl/fl mice, Prx1-Cre, Tet1fl/fl Tet2fl/+Tet3fl/fl mice, Prx1-Cre, Tet1fl/fl Tet2fl/fl Tet3fl/+mice, Prx1-Cre, Tet1fl/HD Tet2fl/fl Tet3fl/fl mice and Prx1-Cre, Tet1+/HD Tet2fl . . .
  

   

  

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