HIGHLIGHTS
- who: August and collaborators from the Michael's Hospital, Canada Jiangsu University, China have published the research: Celastrol ameliorates osteoarthritis via regulating TLR2/NF- κ B signaling pathway, in the Journal: (JOURNAL)
- what: The work demonstrate that celastrol can improve various pathological changes of OA by inhibiting innate immunity and provide an "entry point" for treatment. The study showed the inhibitory effect of celastrol on bone resorption. The authors focused on TLR2 and confirmed that the expression of TLR2 was up-regulated in chondrocytes of both OA patients and OA model rats.
- how: The . . .
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