Novel acylguanidine derivatives targeting smoothened induce antiproliferative and pro-apoptotic effects in chronic myeloid leukemia cells

HIGHLIGHTS

  • who: Alessandra Chiarenza and collaborators from the of Molecular and Developmental Medicine, University of Siena, Siena, Italy, of have published the Article: Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells, in the Journal: PLOS ONE | DOI:10.1371/journal.pone [0149919]. March 2, 2016 of November/10,/2015
  • what: Funding: This work has received financial support from the Istituto Toscano Tumori. The study has proven that MRT92 is certainly a promising therapeutic compound, and the best candidate for further experimental investigations.
  • how: This result is . . .

     

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