HIGHLIGHTS
- who: Simran from the DepartmentState University have published the article: Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth, in the Journal: (JOURNAL)
SUMMARY
Loss of Drosophila TRIM32, encoded by thin (tn), shows reduced levels of glycolytic intermediates and amino_acids. This altered metabolic profile correlates with a reduction in the size of glycolytic larval muscle and brain tissue. Consistent with a role for metabolic intermediates in glycolysis-driven biomass production, dietary amino_acid supplementation in tn mutants improves muscle mass. Remarkably, TRIM32 is also required for ectopic growth - loss of TRIM32 in a . . .
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