Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of alzheimer’s disease

HIGHLIGHTS

  • who: C Scuderi from the DepartmentSAPIENZA University Rome, Italy have published the Article: Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer’s disease, in the Journal: (JOURNAL)
  • what: The authors aimed to study the effects of PEA in a rat model of AD and here, the authors provide the first in_vivo evidence that PEA exerts simultaneously anti-inflammatory and neuroprotective effects. The authors demonstrate the ability of PEA to reduce the expression of BACE1 and APP, proteins directly involved in the amyloidogenic pathway. This investigation provides evidence that PEA . . .

     

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