HIGHLIGHTS
- who: Magali Hennion from the Institut de Biologie de l'Ecole Paris, France have published the paper: FORK-seq: replication landscape of the Saccharomyces cerevisiae genome by nanopore sequencing, in the Journal: (JOURNAL)
- what: Using FORK-seq, the authors report here independent evidence for dispersed initiation, although the authors find that only 9% of all initiation events occur > 2 kb from a known origin (see below). The authors provide evidence that dispersed initiation events are barely if at all enriched in ACS motifs typical of site-specific initiation events and inefficiently recruit ORC and Mcm2 . . .
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