The impact of transcription-mediated replication stress on genome instability and human disease

HIGHLIGHTS

  • who: Stefano Gnan from the Curie Institute, PSL Research University, CNRS, UMR, Paris, France have published the Article: The impact of transcription-mediated replication stress on genome instability and human disease, in the Journal: (JOURNAL)
  • what: In this review, the authors focus on transcription-mediated replication stress and its impact on human diseases. The authors report mainly dynamics from budding yeast and integrate with information from other eukaryotes. The RFD profile agrees with the model shown in_(a), with two strong initiation zones (identified as upward transitions on the RFD profile, indicated by the blue . . .

     

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