The physical origin of rate promoting vibrations in enzymes revealed by structural rigidity

HIGHLIGHTS

  • who: Yann Chalopin from the LaboratoireUniversity of have published the research: The physical origin of rate promoting vibrations in enzymes revealed by structural rigidity, in the Journal: Scientific Reports Scientific Reports of 13/06/2020
  • what: The approach provides a physical rationale that explains the emergence of a biological function (the exploration to a more effective transition_state barrier through thermal vibrations) as a tradeoff between order and disorder, which would be more appropriately termed continuity/discontinuity.

SUMMARY

    The hamiltonian of the molecule can be generally written as H=Ei i where . . .

     

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