Rapid dose-dependent natural killer (nk) cell modulation and cytokine responses following human rvsv-zebov ebolavirus vaccination

HIGHLIGHTS

• who: David Pejoski from the (UNIVERSITY) have published the Article: Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination, in the Journal: (JOURNAL) of 16/Oct/2019
• what: This study shows that the dose of rVSV-ZEBOV impacts circulating NK cell responses because heightened activation (increased NKG2D5 and CD566), depletion of NK cells and many inverse correlations between plasma cytokine levels and percentages of potentially inhibitory KIR+ CD56dim or numbers of cytokine-responsive CD56bright NK cells were only detected after HD vaccination.

SUMMARY

 



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