Free fatty acids shift insulin-induced hepatocyte proliferation towards cd95-dependent apoptosis*

HIGHLIGHTS

• who: Annika Sommerfeld from the Annika Sommerfeld, Roland Reinehr, and Dieter Häussinger, From the Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf, Düsseldorf, Germany Background: Hyperinsulinemia and increased blood levels of free fatty acids (FFA) trigger non-alcoholic steatohepatitis (NASH)Results: Insulin induces EGFR-activation and proliferation. In presence of FFA, however, insulin triggers apoptosis as EGFR triggers CD95-activation JNK-dependently. Conclusions: Insulin-induced EGFR-activation triggers proliferation, but shifts to CD95-dependent apoptosis when a JNKsignal is provided by FFA. Significance: The study provides new insights into the pathogenesis . . .
  

   

  

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