Recruitment of the swi/snf chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-i*

HIGHLIGHTS

• who: Kwang Won Jeong from the Kwang Won Jeong, Young-Ho Lee, and Michael RStallcup, From the Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California , ATP-dependent chromatin remodeling complexes, such as SWI/SNF, are required for transcriptional activation of specific genes and are believed to be recruited to gene promoters by direct interaction with DNA binding transcription factors. However, we report here that recruitment of SWI/SNF to target genes of estrogen receptor ␣ (ER␣) requires the previously described nuclear receptor coactivator protein Flightless-I (FliI). Fli-I . . .
  

   

  

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