Hydroxy-γ-sanshool from zanthoxylum bungeanum (prickly ash) induces apoptosis of human colorectal cancer cell by activating p53 and caspase 8

HIGHLIGHTS

  • who: Liu Xiong from the Jiangsu Academy of Agricultural Sciences (JAAS), China Urmia University, Iran have published the Article: Hydroxy-γ-sanshool from Zanthoxylum bungeanum (prickly ash) induces apoptosis of human colorectal cancer cell by activating P53 and Caspase 8, in the Journal: (JOURNAL)

SUMMARY

    Underlying mechanisms may be activation-induced apoptosis and cell cycle arrest, through cell signaling pathways (NF-κB, Wnt/β-catenin, ERK/MAPK, and PI3K/Akt/mTOR). The HCT-116 cells and HEK293T_cells with a density of 3 × 105 cells/well were exposed to HRS (0, 50, 90, or 130 µM . . .

     

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