Detection of reaction intermediates during human cystathionine β-synthase-monitored turnover and h2s production*

HIGHLIGHTS

• who: Pramod Kumar Yadav from the Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, have published the research work: Detection of Reaction Intermediates during Human Cystathionine β-Synthase-monitored Turnover and H2S Production*, in the Journal: (JOURNAL) of DECEMBER/21,/2012
• what: The authors employed difference stopped-flow spectroscopy to characterize reaction intermediates formed under catalytic conditions. This study provides the first insights into the pre-steady-state kinetic mechanism of human CBS and indicates that the reaction is likely to be limited by a conformational change leading to product release.
 



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