Hepatocyte nuclear factor-4α mediates redox sensitivity of inducible nitric-oxide synthase gene transcription*

HIGHLIGHTS

• who: Hongtao Guo from the The underlying redox-sensitive mechanisms that reg- have demonstrated previously that oxidative stress induced by ulate hepatocyte expression of inducible nitric-oxide benzenetriol (BZT)-mediated superoxide production increases synthase (iNOS) and its antioxidant functions are IL-1␤-induced iNOS protein synthesis, steady state iNOS largely unknownWe have demonstrated previously mRNA expression, NO production, iNOS gene transcription, that oxidative stress induced by benzenetriol-mediated and trans-activation of the iNOS promoter in primary cultures superoxide production increases interleukin-1␤-in- of rat hepatocytes (9, ). Using a transient expression assay in duced iNOS protein . . .
  

   

  

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