Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal s6 kinases

HIGHLIGHTS

• who: Jacob Lauwring Andersen from the Department Aarhus University have published the research work: Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors propose that the tightly packed environment of the DMF-modified C599 site (RSK2) provides a robust inhibition of RSK/MSK kinases (Fig 5).

SUMMARY

Several mechanisms of action (MOA) have been proposed. DMF furthermore reduces neutrophil recruitment in inflammation8 and reduces microglial and astrocytic inflammation9. RSK1, 2, and 3 are ubiquitously expressed in human . . .

 



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