The n-terminal region of twitchin binds thick and thin contractile filaments

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• who: Thomas M. Butler from the Thomas MButler1, Susan U. Mooers, Srinivasa R. Narayan, and Marion J. Siegman From the Department of Molecular Physiology and Biophysics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania , Catch force maintenance in invertebrate smooth muscles is probably mediated by a force-bearing tether other than myosin cross-bridges between thick and thin filaments. The phosphorylation state of the mini-titin twitchin controls catch. The Cterminal phosphorylation site (D2) of twitchin with its flanking Ig domains forms a phosphorylation-sensitive complex with actin and myosin, suggesting that twitchin is the tether (Funabara . . .
  

   

  

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