A phase i trial of dfmo targeting polyamine addiction in patients with relapsed/refractory neuroblastoma

HIGHLIGHTS

  • who: Giselle L. Saulnier Sholler and collaborators from the Institute, UNITED Medicine, Michigan State University, Grand Rapids, Michigan, United, Cancer have published the paper: A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma, in the Journal: PLOS ONE | DOI:10.1371/journal.pone [0127246]. May 27, 2015 of May/27,/2015
  • what: This study investigated safety response pharmacokinetics genetic and metabolic factors associated with ODC in clinical trial the ODC inhibitor difluoromethylornithine (DFMO) ± etoposide for patients with relapsed or NB. To address the safety issue, patient replacement was allowed . . .

     

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