Blocking pdgf-cc signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier

HIGHLIGHTS

• who: Manuel Zeitelhofer from the DivisionKarolinska University have published the research work: Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier, in the Journal: Scientific Reports Scientific Reports
• what: Since PDGFRα is expressed in perivascular cells in the ­NVU57,61 the authors aimed to investigate whether interfering with the PDGF-CC/PDGFRα axis is responsible for the imatinib-mediated preservation of BBB integrity in EAE by analyzing the effect of genetically reducing PDGF-CC levels utilizing Pdgfc deficient mice and neutralizing PDGF-CC monoclonal_antibodies (mAb), respectively, in . . .
  

   

  

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