HIGHLIGHTS
- who: Microbiology from the Washington University have published the research: Effective Control of Chronic c -Herpesvirus Infection by Unconventional MHC Class Ia-Independent CD8 T Cells, in the Journal: (JOURNAL)
- what: The authors show here that mice lacking MHC Class Ia molecules (Kb/xDb/ mice) effectively control chronic c-herpesvirus 68 (cHV68) infection via a robust expansion of b2-microglobulin (b2-m)-dependent but CD1d-independent unconventional CD8 T cells. Enormous efforts have gone into characterizing the role of conventional CD8 T_cells that recognize viral peptides together with MHC Class Ia molecules during chronic viral . . .
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