Synergistic anion and metal binding to the ferric ion-binding protein from neisseria gonorrhoeae *210

HIGHLIGHTS

• who: Maolin Guo from the ture of Fe-PO4-FBP compared with Fe䡠CO3䡠FBP as a result of bond length and angle changes together with a significant difference in local orderingEXAFS data allowed the refinement of the crystallographically determined metal-ligand bond lengths and suggested that the water, Glu, and monodentate synergistic anion are involved in an, bonding network around the Fe site. The accurate structure of the Fe/anion site provides a reliable structural basis for rational design of novel chemotherapeutic agents targeted on this key protein, which is required for virulence and iron uptake . . .
  

   

  

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