Preventing atp degradation by aso-mediated knockdown of cd39 and cd73 results in a2ar-independent rescue of t cell proliferation

HIGHLIGHTS

• who: Julia Festag from the Pharmaceuticals GmbH and CoKG, Planegg/Martinsried, Germany have published the research work: Preventing ATP Degradation by ASO-Mediated Knockdown of CD39 and CD73 Results in A2aR-Independent Rescue of T Cell Proliferation, in the Journal: (JOURNAL) of 21/09/2020
• what: The authors demonstrate that treatment of human T_cells with LNA-modified ASOs specific for human CD39 and CD73 results in potent target knockdown in_vitro without the use of a transfection reagent. The authors show that a microenvironmental factor produced by ATP degradation, other than adenosine, is responsible for the . . .
  

   

  

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