Xbp1 links the 12-hour clock to nafld and regulation of membrane fluidity and lipid homeostasis

HIGHLIGHTS

• who: Huan Meng from the College University of have published the Article: XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Hepatic dysregulation of glucose and lipid homeostasis are hallmarks of human nonalcoholic fatty liver disease (NAFLD)25,26, and here, the authors show that hepatic ablation of Xbp1 disrupts the 12-h clock, negatively impacts indices of metabolic fitness, and promotes a defined NAFLD phenotype. The authors show that the ablation of Xbp1 disrupts the 12-h clock and . . .
  

   

  

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