HIGHLIGHTS
- who: Haozhe Shi et al. from the University, China have published the research work: CRISPR/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis, in the Journal: (JOURNAL) of 15/03/2010
- what: The authors propose that this impairment of gut microbial homeostasis leads to destruction of gut barrier and enhanced delivery of LPS to the circulation and systemic inflammation . The authors developed a mutant hamster model lacking IL-10 using CRISPR/Cas9 gene editing. The authors report an IL-10 mutant hamster model and characterize the phenotypes caused . . .
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