Transcontinental spread and evolution of mycobacterium tuberculosis w148 european/russian clade toward extensively drug resistant tuberculosis

HIGHLIGHTS

• who: Matthias Merker from the Data collection and whole-genome sequencing The study comprises Mtbc strains obtained for routine diagnostic proceduresNo additional patient material was obtained. Ethical approval was granted by the ethic commission of the University of Lübeck, Germany. Overall, MTBC isolates were identified based on characteristic MTBC genotyping patterns classifying them as , Beijing family. This definition includes isolates with mycobacterial interspersed repetitive units (MIRU) genotype "100-32", as well as a characteristic , restriction fragment length polymorphism (RFLP) banding pattern described previously by Bifani et_al44. Both MIRU genotype, and the characteristic RFLP banding pattern have . . .
  

   

  

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