The predominant role of arrestin3 in general gpcr desensitization in platelets

HIGHLIGHTS

• who: Preeti Kumari Chaudhary et al. from the Laboratory of Veterinary Pathology and Platelet Signaling, College of Veterinary Medicine, Chungbuk National have published the paper: The Predominant Role of Arrestin3 in General GPCR Desensitization in Platelets, in the Journal: (JOURNAL)
• what: The authors show that arrestin3, but not arrestin2, potentiates platelet aggregation 3 of 12 and secretion induced by agonists such as ADP, AYPGKF, thrombin, and U46619. The authors demonstrate that arrestin3, not arrestin2, plays a central role in regulating GPCR-mediated platelet functional responses and thrombus formation in_vivo through general GPCR desensitization.
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