Trim7 restricts coxsackievirus and norovirus infection by detecting the c-terminal glutamine generated by 3c protease processing

HIGHLIGHTS

  • who: Jakub Luptak et al. from the Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital have published the article: TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing, in the Journal: Viruses 2022, 1610 of /2022/
  • what: The authors show that s extreme substrate promiscuity is due to a highly unusual binding mechanism in which the PRYSPRY domain captures any ligand with a C-terminal helix that terminates in a hydrophobic residue followed by a glutamine. The authors sought to determine how TRIM7 . . .

     

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