HIGHLIGHTS
- who: Sanaz Dastghaib and colleagues from the Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran have published the research: Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells, in the Journal: (JOURNAL)
- what: The authors showed that co-treatment of Simva with TMZ (Simva-TMZ) increased the Confirming findings from previous studies, the authors showed that Simva-TMZ inhibited autophagy flux ; the authors demonstrate here for the first time that this is dependent on the IRE1-XBP-1s axis (as MKC-8866 inhibited the Simva . . .
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