Trpm6 and trpm7 differentially contribute to the relief of heteromeric trpm6/7 channels from inhibition by cytosolic mg2+ and mg·atp

HIGHLIGHTS

• who: Silvia Ferioli from the (UNIVERSITY) have published the article: TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP, in the Journal: (JOURNAL) of 31/01/2017
• what: The authors show that mTRPM6 and mTRPM7 differentially contribute to regulatory characteristics of heteromeric mTRPM6/7 channel complexes: mTRPM7 is able to offset the very high sensitivity of mTRPM6 to cytosolic Mg2+ to physiologically relevant concentrations, whereas mTRPM6 relieves mTRPM7 from inhibition by Mg·ATP.

SUMMARY

Received Published: xx xx xxxx . . .

 



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