HIGHLIGHTS
- who: Toshihiro Ogawa et al. from the Okayama University, Japan have published the paper: Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of gastric cancer, in the Journal: (JOURNAL) of 25/06/2022
- what: This study investigated the efficacy of replicative oncolytic adenovirus-mediated p53 gene therapy (OBP-702) against CAFs and peritoneal metastasis of gastric cancer (GC). This study demonstrated that CAFs acquired tumor-supportive properties by the transcriptional alteration of p53 in CAFs.
- how: In several phase III trials i.p. chemotherapy showed superior survival benefits compared with . . .
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