Natd promotes lung cancer progression by preventing histone h4 serine phosphorylation to activate slug expression

HIGHLIGHTS

• who: Junyi Ju from the School Nanjing University, Nanjing, China have published the Article: NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that NatD-mediated N-α-terminal acetylation of histone H4 promotes lung cell invasion through antagonizing serine phosphorylation of histone H4 by CK2α This process is depicted in the model shown in Fig 8. This study demonstrated that NatD can trigger Nt-acetylation of histone H4 on the Slug promoter to promote 10 EMT of lung . . .
  

   

  

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