Role of the circadian clock “death-loop” in the dna damage response underpinning cancer treatment resistance

HIGHLIGHTS

  • who: Ninel Miriam Vainshelbaum and colleagues from the Faculty of Biology, University of Latvia, Riga, Latvia have published the Article: Role of the Circadian Clock “Death-Loop” in the DNA Damage Response Underpinning Cancer Treatment Resistance, in the Journal: Cells 2022, 880 of /2022/
  • what: The authors report an intriguing positive correlation between cancer WGD and the deregulation of the CC assessed by cells undergoing mitotic slippage cast off telomere fragments with TERT restore the telomeres by ALT-recombination and return their depolyploidised offspring to telomerase-dependent regulation. In the study , the upregulated OCT4 alongside . . .

     

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