Ager expression and alternative splicing in bronchial biopsies of smokers and never smokers

HIGHLIGHTS

• who: Alen Faiz from the signaling is best characterized in COPDThe gene encoding RAGE, has been shown to be a susceptibility gene for COPD [3]. Furthermore, sRAGE levels are decreased in COPD patients [4], while the levels of several RAGE ligands are increased both locally and systemically [5], indicating increased RAGE signaling. However, the effect of smoking on RAGE signaling is less well studied. It was shown that stimulation of gingival carcinoma epithelial cells with cigarette smoke extract (CSE) increases RAGE expression and the subsequent inflammatory reaction and induces oral squamous cell carcinoma cell invasion [6]. Furthermore . . .
  

   

  

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