Genome-wide transcriptional effects of the anti-cancer agent camptothecin

HIGHLIGHTS

  • who: Agent Camptothecin et al. from the Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center and Translational Oncology Program, University of Michigan, AnnEditor: Didier Auboeuf, INSERM, France have published the research work: Genome-Wide Transcriptional Effects of the Anti-Cancer Agent Camptothecin, in the Journal: PLOS ONE | www.plosone.org of October/23,/2013
  • what: The authors used Bru-Seq to explore the acute effects of camptothecin on various aspects of transcription and found that camptothecin (i) inhibited elongation of transcription, (ii) stimulated transcriptional readthrough past the 3'-end of small genes, (iii . . .

     

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