The class 3 pi3k coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor pparα

HIGHLIGHTS

• who: Anton Iershov from the CNRS, Paris, France, Pediatric Hepatology Unit, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France. University of have published the paper: The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that hepatic expression of the class 3 PI3K is essential for metabolic adaptation to starvation in the liver through the control of PPARα transcriptional activity. The authors demonstrate that the availability of PPARα ligands and expression of co-activator . . .
  

   

  

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