Gwas and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

HIGHLIGHTS

• who: GWAS and collaborators from the therosclerosis is characterized by an accumulation of lipid-rich and inflammatory deposits (plaques) in the subintimal space of medium and large arteriesPlaque enlargement leads to blood flow limitation, organ ischemia, and/ or tissue necrosis. Plaque rupture can lead to abrupt vascular occlusion, which underlies clinical cardiovascular events, including myocardial infarction and ischemic stroke. Coronary heart disease (CHD) accounts for one in seven deaths, and stroke accounts for one in , deaths in the US1. Because atherosclerosis has a long pre-clinical phase, early detection of atherosclerosis using non-invasive methods may help . . .
  

   

  

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