A recombinant measles virus vaccine strongly reduces shiv viremia and virus reservoir establishment in macaques

HIGHLIGHTS

• who: Patrycja Nzounza from the (UNIVERSITY) have published the paper: A recombinant measles virus vaccine strongly reduces SHIV viremia and virus reservoir establishment in macaques, in the Journal: (JOURNAL)
• what: The authors show that MVSHIV vaccination reduced challenge virus infection by a hundredfold, rapidly controlled its propagation, and limited cell-reservoir establishment resulting in 50% of animals with undetectable viral and proviral load. In this pilot study, the authors show that vaccination with liveattenuated MV expressing SHIV antigens did not significantly affect the number of SHIV-SF162p3 challenges required to achieve infection relative to control . . .
  

   

  

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